A Novel Method for the Rapid, Non-Aqueous t-Butoxycarbonylation of Some O-Labeled Amino Acids and O-N.M.R. Parameters of the Products

E. Ponnusamy; U. Fotadar; A. Spisni; D. Fiat

doi:10.1055/s-1986-31473

Synthesis 1986; 1986(1): 48-49
DOI: 10.1055/s-1986-31473

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A Novel Method for the Rapid, Non-Aqueous t-Butoxycarbonylation of Some ¹⁷ O-Labeled Amino Acids and ¹⁷O-N.M.R. Parameters of the Products

E. Ponnusamy^* , U. Fotadar, A. Spisni, D. Fiat

^*Department of Physiology and Biophysics, University of Illinois at Chicago, Health Sciences Center, P.O. Box 6998, Chicago, Illinois 60680, U. S. A.

Abstract

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¹⁷ O-Labeled amino acids are t-butoxycarbonylated without loss of ¹⁷ O-labeling by reaction with triethylamine and di-t-butyl dicarbonate in methanol or dimethylformamide and cleavage of the resultant t-butoxycarbonylamino acid ammonium salt by brief treatment with ice-cold dilute hydrochloric acid at pH 2.15.

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A Novel Method for the Rapid, Non-Aqueous t-Butoxycarbonylation of Some 17 O-Labeled Amino Acids and 17O-N.M.R. Parameters of the Products

A Novel Method for the Rapid, Non-Aqueous t-Butoxycarbonylation of Some ¹⁷ O-Labeled Amino Acids and ¹⁷O-N.M.R. Parameters of the Products